Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/14/22 2:00 PM | 5/14/22 2:00 PM | Toronto FC | Orlando City | 0-1 | 5 - 7 points |
| 5/14/22 2:30 PM | 5/14/22 2:30 PM | Colorado Rapids | Los Angeles FC | 2-0 | 5 - 7 points |
| 5/14/22 6:00 PM | 5/14/22 6:00 PM | New York City FC | Columbus Crew | 2-0 | 5 - 7 points |
| 5/14/22 6:00 PM | 5/14/22 6:00 PM | Charlotte FC | CF Montreal | 0-2 | 5 - 7 points |
| 5/14/22 6:00 PM | 5/14/22 6:00 PM | Vancouver Whitecaps | San Jose Earthquakes | 3-3 | 5 - 7 points |
| 5/14/22 6:30 PM | 5/14/22 6:30 PM | Philadelphia Union | New York Red Bulls | 1-1 | 5 - 7 points |
| 5/14/22 7:00 PM | 5/14/22 7:00 PM | Inter Miami CF | D.C. United | 2-2 | 5 - 7 points |
| 5/14/22 7:00 PM | 5/14/22 7:00 PM | Chicago Fire | Cincinnati FC | 1-2 | 5 - 7 points |
| 5/14/22 7:30 PM | 5/14/22 7:30 PM | Houston Dynamo | Nashville SC | 2-0 | 5 - 7 points |
| 5/14/22 8:30 PM | 5/14/22 8:30 PM | Real Salt Lake | Austin FC | 2-1 | 5 - 7 points |
| 5/14/22 9:00 PM | 5/14/22 9:00 PM | Portland Timbers | Sporting Kansas City | 7-2 | 5 - 7 points |
| 5/14/22 9:30 PM | 5/14/22 9:30 PM | Los Angeles Galaxy | FC Dallas | 1-3 | 5 - 7 points |
| 5/15/22 12:55 PM | 5/15/22 12:55 PM | Atlanta United FC | New England Revolution | 2-2 | 5 - 7 points |
| 5/15/22 3:00 PM | 5/15/22 3:00 PM | Seattle Sounders | Minnesota United FC | 3-1 | 5 - 7 points |