Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/7/22 2:30 PM | 5/7/22 2:30 PM | Charlotte FC | Inter Miami CF | 1-0 | 5 - 7 points |
| 5/7/22 3:00 PM | 5/7/22 3:00 PM | CF Montreal | Orlando City | 4-1 | 5 - 7 points |
| 5/7/22 5:00 PM | 5/7/22 5:00 PM | Atlanta United FC | Chicago Fire | 4-1 | 5 - 7 points |
| 5/7/22 6:00 PM | 5/7/22 6:00 PM | New York City FC | Sporting Kansas City | 0-0 | 5 - 7 points |
| 5/7/22 6:00 PM | 5/7/22 6:00 PM | New York Red Bulls | Portland Timbers | 1-1 | 5 - 7 points |
| 5/7/22 6:30 PM | 5/7/22 6:30 PM | New England Revolution | Columbus Crew | 2-2 | 5 - 7 points |
| 5/7/22 6:30 PM | 5/7/22 6:30 PM | D.C. United | Houston Dynamo | 2-0 | 5 - 7 points |
| 5/7/22 7:00 PM | 5/7/22 7:00 PM | Minnesota United FC | Cincinnati FC | 0-1 | 5 - 7 points |
| 5/7/22 7:30 PM | 5/7/22 7:30 PM | FC Dallas | Seattle Sounders | 2-0 | 5 - 7 points |
| 5/7/22 9:00 PM | 5/7/22 9:00 PM | San Jose Earthquakes | Colorado Rapids | 1-0 | 5 - 7 points |
| 5/7/22 10:00 PM | 5/7/22 10:00 PM | Los Angeles FC | Philadelphia Union | 2-2 | 5 - 7 points |
| 5/8/22 3:00 PM | 5/8/22 3:00 PM | Vancouver Whitecaps | Toronto FC | 1-0 | 5 - 7 points |
| 5/8/22 4:00 PM | 5/8/22 4:00 PM | Nashville SC | Real Salt Lake | 2-0 | 5 - 7 points |
| 5/8/22 6:00 PM | 5/8/22 6:00 PM | Austin FC | Los Angeles Galaxy | 0-1 | 5 - 7 points |