Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 7/1/21 8:30 PM | 7/1/21 8:30 PM | Austin FC | Portland Timbers | 4-1 | 5 - 7 points |
| 7/3/21 4:00 PM | 7/3/21 4:00 PM | Columbus Crew | New England Revolution | 2-2 | 5 - 7 points |
| 7/3/21 4:30 PM | 7/3/21 4:30 PM | D.C. United | Toronto FC | 7-1 | 5 - 7 points |
| 7/3/21 6:30 PM | 7/3/21 6:30 PM | CF Montreal | Inter Miami CF | 1-0 | 5 - 7 points |
| 7/3/21 6:30 PM | 7/3/21 6:30 PM | Orlando City | New York Red Bulls | 1-2 | 5 - 7 points |
| 7/3/21 7:00 PM | 7/3/21 7:00 PM | Nashville SC | Philadelphia Union | 1-0 | 5 - 7 points |
| 7/3/21 7:00 PM | 7/3/21 7:00 PM | Minnesota United FC | San Jose Earthquakes | 2-2 | 5 - 7 points |
| 7/3/21 7:00 PM | 7/3/21 7:00 PM | Chicago Fire | Atlanta United FC | 3-0 | 5 - 7 points |
| 7/3/21 7:30 PM | 7/3/21 7:30 PM | Houston Dynamo | Cincinnati FC | 1-1 | 5 - 7 points |
| 7/3/21 9:00 PM | 7/3/21 9:00 PM | Real Salt Lake | Los Angeles FC | 0-1 | 5 - 7 points |
| 7/4/21 7:30 PM | 7/4/21 7:30 PM | FC Dallas | Vancouver Whitecaps | 2-2 | 5 - 7 points |
| 7/4/21 8:00 PM | 7/4/21 8:00 PM | Colorado Rapids | Seattle Sounders | 1-1 | 5 - 7 points |
| 7/4/21 9:30 PM | 7/4/21 9:30 PM | Los Angeles Galaxy | Sporting Kansas City | 0-2 | 5 - 7 points |