Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/30/22 12:30 PM | 4/30/22 12:30 PM | Houston Dynamo | Austin FC | 1-2 | 5 - 7 points |
| 4/30/22 2:00 PM | 4/30/22 2:00 PM | Toronto FC | Cincinnati FC | 1-2 | 5 - 7 points |
| 4/30/22 2:30 PM | 4/30/22 2:30 PM | Real Salt Lake | Los Angeles Galaxy | 1-0 | 5 - 7 points |
| 4/30/22 3:00 PM | 4/30/22 3:00 PM | CF Montreal | Atlanta United FC | 2-1 | 5 - 7 points |
| 4/30/22 6:30 PM | 4/30/22 6:30 PM | Columbus Crew | D.C. United | 3-0 | 5 - 7 points |
| 4/30/22 6:30 PM | 4/30/22 6:30 PM | New England Revolution | Inter Miami CF | 2-0 | 5 - 7 points |
| 4/30/22 6:30 PM | 4/30/22 6:30 PM | Orlando City | Charlotte FC | 2-1 | 5 - 7 points |
| 4/30/22 7:00 PM | 4/30/22 7:00 PM | Chicago Fire | New York Red Bulls | 1-2 | 5 - 7 points |
| 4/30/22 7:30 PM | 4/30/22 7:30 PM | Sporting Kansas City | FC Dallas | 2-2 | 5 - 7 points |
| 4/30/22 8:00 PM | 4/30/22 8:00 PM | Colorado Rapids | Portland Timbers | 2-0 | 5 - 7 points |
| 5/1/22 12:00 PM | 5/1/22 12:00 PM | New York City FC | San Jose Earthquakes | 3-0 | 5 - 7 points |
| 5/1/22 3:00 PM | 5/1/22 3:00 PM | Nashville SC | Philadelphia Union | 1-1 | 5 - 7 points |
| 5/1/22 9:00 PM | 5/1/22 9:00 PM | Los Angeles FC | Minnesota United FC | 2-0 | 5 - 7 points |
| 6/14/22 9:30 PM | 6/14/22 9:30 PM | Seattle Sounders | Vancouver Whitecaps | 4-0 | 5 - 7 points |