| Date | Home | Away | Result |
|---|---|---|---|
| 9/16/26 11:45 AM | FC Ararat-Armenia | Sparta Prag | 1-4 |
| 9/16/26 11:45 AM | Omonia Nicosia | Celta Vigo | 1-0 |
| 9/16/26 2:00 PM | Bayer 04 Leverkusen | NK Celje | 2-0 |
| 9/16/26 2:00 PM | AC Milan | Benfica Lisbon | 0-2 |
| 9/16/26 2:00 PM | Hapoel Beer Sheva | Dinamo Zagreb | 0-0 |
| 9/16/26 2:00 PM | Olympiakos Piräus | Jagiellonia Bialystok | 2-1 |
| 9/16/26 2:00 PM | RSC Anderlecht | Olympique Lyon | 1-2 |
| 9/16/26 2:00 PM | SK Sturm Graz | Stade Rennes | 0-0 |
| 9/16/26 2:00 PM | AFC Sunderland | AZ Alkmaar | 1-0 |
| 9/17/26 11:45 AM | OFI Crete | 1899 Hoffenheim | 2-0 |
| 9/17/26 11:45 AM | Levski Sofia | FC Red Bull Salzburg | 0-1 |
| 9/17/26 2:00 PM | Besiktas Istanbul | Olympique Marseille | 4-1 |
| 9/17/26 2:00 PM | Celtic Glasgow | Ferencvaros Budapest | 1-3 |
| 9/17/26 2:00 PM | Crystal Palace | Lech Poznan | 4-0 |
| 9/17/26 2:00 PM | Viktoria Plzen | Royale Union Saint-Gilloise | 0-3 |
| 9/17/26 2:00 PM | Juventus Turin | NEC Nijmwegen | 5-0 |
| 9/17/26 2:00 PM | Lillestroem SK | SCU Torreense | 1-2 |
| 9/17/26 2:00 PM | Real Sociedad | AFC Bournemouth | 1-2 |