| Date | Home | Away | Result |
|---|---|---|---|
| 9/26/26 6:30 PM | Atlanta United FC | New York City FC | 2-2 |
| 9/26/26 6:30 PM | Charlotte FC | Chicago Fire | 0-1 |
| 9/26/26 6:30 PM | Philadelphia Union | Orlando City | 4-2 |
| 9/26/26 6:30 PM | CF Montreal | Cincinnati FC | 3-1 |
| 9/26/26 7:30 PM | Austin FC | San Diego FC | 3-3 |
| 9/26/26 7:30 PM | Nashville SC | Toronto FC | 2-0 |
| 9/26/26 7:30 PM | FC Dallas | Los Angeles FC | 1-0 |
| 9/26/26 7:30 PM | Houston Dynamo | Sporting Kansas City | 0-2 |
| 9/26/26 7:30 PM | Seattle Sounders | Minnesota United FC | 3-1 |
| 9/26/26 8:30 PM | Real Salt Lake | New England Revolution | 3-0 |
| 9/26/26 9:30 PM | Los Angeles Galaxy | Colorado Rapids | 3-2 |
| 9/26/26 9:30 PM | San Jose Earthquakes | Portland Timbers | 3-1 |
| 9/26/26 9:30 PM | Vancouver Whitecaps | D.C. United | 3-3 |
| 9/27/26 6:00 PM | Columbus Crew | Inter Miami CF | 2-1 |
| 9/30/26 6:30 PM | New York Red Bulls | St. Louis City SC | 0-3 |