| Date | Home | Away | Result |
|---|---|---|---|
| 4/25/26 12:00 PM | Toronto FC | Atlanta United FC | 1-2 |
| 4/25/26 1:30 PM | CF Montreal | New York City FC | 1-0 |
| 4/25/26 3:45 PM | Minnesota United FC | Los Angeles FC | 0-1 |
| 4/25/26 6:30 PM | Cincinnati FC | New York Red Bulls | 2-0 |
| 4/25/26 6:30 PM | Inter Miami CF | New England Revolution | 1-1 |
| 4/25/26 6:30 PM | Columbus Crew | Philadelphia Union | 2-0 |
| 4/25/26 6:30 PM | D.C. United | Orlando City | 3-2 |
| 4/25/26 7:30 PM | Chicago Fire | Sporting Kansas City | 5-0 |
| 4/25/26 7:30 PM | Austin FC | Houston Dynamo | 2-0 |
| 4/25/26 7:40 PM | Nashville SC | Charlotte FC | 4-2 |
| 4/25/26 7:40 PM | St. Louis City SC | San Jose Earthquakes | 2-3 |
| 4/25/26 8:40 PM | San Diego FC | Portland Timbers | 1-2 |
| 4/25/26 9:30 PM | Vancouver Whitecaps | Colorado Rapids | 3-1 |
| 4/25/26 9:30 PM | Seattle Sounders | FC Dallas | 2-1 |
| 4/26/26 6:00 PM | Los Angeles Galaxy | Real Salt Lake | 2-1 |