| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 4/28/26 5:00 PM | CA Lanus | LDU Quito | Group G | 1-0 |
| 4/28/26 5:00 PM | Club Libertad | Independiente del Valle | Group H | 2-3 |
| 4/28/26 7:00 PM | Universidad Central | Rosario Central | Group H | 0-3 |
| 4/28/26 7:30 PM | Cruzeiro | Boca Juniors | Group D | 1-0 |
| 4/28/26 9:00 PM | Deportes Tolima | Coquimbo Unido | Group B | 3-0 |
| 4/28/26 9:00 PM | Sporting Cristal | Junior FC | Group F | 2-0 |
| 4/29/26 5:00 PM | Mirassol FC | Always Ready | Group G | 2-0 |
| 4/29/26 5:00 PM | CA Platense | Union Santa Fe | Group E | 2-1 |
| 4/29/26 7:00 PM | Barcelona SC | Universidad Católica | Group D | 1-2 |
| 4/29/26 7:30 PM | Estudiantes de La Plata | Flamengo | Group A | 1-1 |
| 4/29/26 7:30 PM | Club Cerro Porteno | Palmeiras | Group F | 1-1 |
| 4/29/26 9:00 PM | Universitario | Club Nacional de Football | Group B | 4-2 |
| 4/30/26 5:00 PM | Club Bolívar | Fluminense | Group C | 2-0 |
| 4/30/26 5:00 PM | Independiente Rivadavia | Deportivo La Guaira | Group C | 4-1 |
| 4/30/26 7:00 PM | Corinthians | Club Atlético Peñarol | Group E | 2-0 |
| 4/30/26 9:00 PM | Independiente Medellín | Cusco FC | Group A | 1-0 |