| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 4/14/26 5:00 PM | Club Nacional de Football | Deportes Tolima | Group B | 3-1 |
| 4/14/26 5:00 PM | Club Cerro Porteno | Junior FC | Group F | 1-0 |
| 4/14/26 5:00 PM | Estudiantes de La Plata | Cusco FC | Group A | 2-1 |
| 4/14/26 7:00 PM | Boca Juniors | Barcelona SC | Group D | 3-0 |
| 4/14/26 7:00 PM | Club Bolívar | Deportivo La Guaira | Group C | 1-1 |
| 4/14/26 9:00 PM | Universitario | Coquimbo Unido | Group B | 0-2 |
| 4/14/26 9:00 PM | LDU Quito | Mirassol FC | Group G | 2-0 |
| 4/15/26 5:00 PM | Cruzeiro | Universidad Católica | Group D | 1-2 |
| 4/15/26 5:00 PM | Club Libertad | Rosario Central | Group H | 0-1 |
| 4/15/26 7:30 PM | Fluminense | Independiente Rivadavia | Group C | 1-2 |
| 4/15/26 7:30 PM | Corinthians | Union Santa Fe | Group E | 2-0 |
| 4/15/26 9:00 PM | Independiente del Valle | Universidad Central | Group H | 3-1 |
| 4/16/26 5:00 PM | Palmeiras | Sporting Cristal | Group F | 2-1 |
| 4/16/26 5:00 PM | CA Lanus | Always Ready | Group G | 1-0 |
| 4/16/26 7:30 PM | Flamengo | Independiente Medellín | Group A | 4-1 |
| 4/16/26 7:30 PM | Club Atlético Peñarol | CA Platense | Group E | 1-2 |