| Date | Home | Away | Result |
|---|---|---|---|
| 9/12/25 1:30 PM | US Avellino | AC Monza | 2-1 |
| 9/13/25 8:00 AM | Cagliari Calcio | Parma Calcio 1913 | 2-0 |
| 9/13/25 8:00 AM | Juve Stabia | AC Reggiana 1919 | 0-0 |
| 9/13/25 8:00 AM | Modena FC | SSC Bari | 3-0 |
| 9/13/25 8:00 AM | Padova Calcio | Frosinone Calcio | 0-1 |
| 9/13/25 8:00 AM | Pescara Calcio | FC Venice | 2-2 |
| 9/13/25 10:15 AM | US Catanzaro 1929 | Carrarese Calcio 1908 | 1-1 |
| 9/13/25 11:00 AM | Juventus Turin | Inter Milan | 4-3 |
| 9/13/25 12:30 PM | Sampdoria Genua | FC Cesena | 1-2 |
| 9/13/25 1:45 PM | Fiorentina | SSC Napoli | 1-3 |
| 9/14/25 5:30 AM | AS Roma | FC Turin | 0-1 |
| 9/14/25 8:00 AM | Atalanta Bergamo | US Lecce | 4-1 |
| 9/14/25 8:00 AM | Pisa Sporting Club | Udinese Calcio | 0-1 |
| 9/14/25 8:00 AM | Virtus Entella | Mantova 1911 | 1-0 |
| 9/14/25 10:15 AM | FC Südtirol | Palermo FC | 0-2 |
| 9/14/25 11:00 AM | Sassuolo Calcio | Lazio Rom | 1-0 |
| 9/14/25 12:30 PM | FC Empoli | Spezia Calcio | 1-1 |
| 9/14/25 1:45 PM | AC Milan | FC Bologna | 1-0 |
| 9/15/25 11:30 AM | Hellas Verona | US Cremonese | 0-0 |
| 9/15/25 1:45 PM | Como Calcio | Genua CFC | 1-1 |