| Date | Home | Away | Result |
|---|---|---|---|
| 8/29/25 11:30 AM | US Cremonese | Sassuolo Calcio | 3-2 |
| 8/29/25 1:30 PM | AC Reggiana 1919 | FC Empoli | 3-1 |
| 8/29/25 1:45 PM | US Lecce | AC Milan | 0-2 |
| 8/30/25 11:30 AM | Parma Calcio 1913 | Atalanta Bergamo | 1-1 |
| 8/30/25 11:30 AM | FC Bologna | Como Calcio | 1-0 |
| 8/30/25 12:00 PM | Juve Stabia | FC Venice | 0-0 |
| 8/30/25 12:00 PM | Mantova 1911 | Pescara Calcio | 2-1 |
| 8/30/25 1:45 PM | SSC Napoli | Cagliari Calcio | 1-0 |
| 8/30/25 1:45 PM | Pisa Sporting Club | AS Roma | 0-1 |
| 8/30/25 2:00 PM | FC Cesena | Virtus Entella | 1-1 |
| 8/30/25 2:00 PM | Palermo FC | Frosinone Calcio | 0-0 |
| 8/30/25 2:00 PM | Spezia Calcio | US Catanzaro 1929 | 0-0 |
| 8/31/25 11:30 AM | Genua CFC | Juventus Turin | 0-1 |
| 8/31/25 11:30 AM | FC Turin | Fiorentina | 0-0 |
| 8/31/25 12:00 PM | Carrarese Calcio 1908 | Padova Calcio | 0-0 |
| 8/31/25 12:00 PM | FC Südtirol | Sampdoria Genua | 3-1 |
| 8/31/25 1:45 PM | Lazio Rom | Hellas Verona | 4-0 |
| 8/31/25 1:45 PM | Inter Milan | Udinese Calcio | 1-2 |
| 8/31/25 2:00 PM | SSC Bari | AC Monza | 1-1 |
| 8/31/25 2:00 PM | Modena FC | US Avellino | 1-1 |