| Date | Home | Away | Result |
|---|---|---|---|
| 10/28/25 2:30 PM | Frosinone Calcio | Virtus Entella | 4-0 |
| 10/28/25 2:30 PM | FC Cesena | Carrarese Calcio 1908 | 2-1 |
| 10/28/25 2:30 PM | FC Empoli | Sampdoria Genua | 1-1 |
| 10/28/25 2:30 PM | Pescara Calcio | US Avellino | 1-1 |
| 10/28/25 2:30 PM | AC Reggiana 1919 | Modena FC | 1-0 |
| 10/28/25 2:30 PM | Palermo FC | AC Monza | 0-3 |
| 10/29/25 2:30 PM | Mantova 1911 | US Catanzaro 1929 | 1-3 |
| 10/29/25 2:30 PM | Spezia Calcio | Padova Calcio | 1-1 |
| 10/29/25 2:30 PM | FC Venice | FC Südtirol | 3-0 |
| 11/1/25 9:00 AM | Udinese Calcio | Atalanta Bergamo | 1-0 |
| 11/1/25 12:00 PM | SSC Napoli | Como Calcio | 0-0 |
| 11/1/25 2:45 PM | US Cremonese | Juventus Turin | 1-2 |
| 11/2/25 5:30 AM | Hellas Verona | Inter Milan | 1-2 |
| 11/2/25 8:00 AM | Fiorentina | US Lecce | 0-1 |
| 11/2/25 8:00 AM | FC Turin | Pisa Sporting Club | 2-2 |
| 11/2/25 11:00 AM | Parma Calcio 1913 | FC Bologna | 1-3 |
| 11/2/25 1:45 PM | AC Milan | AS Roma | 1-0 |
| 11/3/25 11:30 AM | Sassuolo Calcio | Genua CFC | 1-2 |
| 11/3/25 1:45 PM | Lazio Rom | Cagliari Calcio | 2-0 |
| 12/4/25 12:30 PM | Juve Stabia | SSC Bari | 0-0 |