| Date | Home | Away | Result |
|---|---|---|---|
| 8/9/25 1:30 PM | Virtus Entella | Ternana Calcio | 4-0 |
| 8/10/25 12:30 PM | Padova Calcio | Vicenza Calcio | 0-2 |
| 8/10/25 1:30 PM | US Avellino | Audace Cerignola | 0-1 |
| 8/10/25 1:30 PM | Pescara Calcio | Rimini FC | 1-0 |
| 8/15/25 11:00 AM | FC Empoli | AC Reggiana 1919 | 4-1a.PSO/1-1FT |
| 8/15/25 11:30 AM | Sassuolo Calcio | US Catanzaro 1929 | 1-0 |
| 8/15/25 1:45 PM | US Lecce | Juve Stabia | 2-0 |
| 8/15/25 2:15 PM | Genua CFC | Vicenza Calcio | 3-0 |
| 8/16/25 11:00 AM | FC Venice | Mantova 1911 | 4-0 |
| 8/16/25 11:30 AM | Como Calcio | FC Südtirol | 3-1 |
| 8/16/25 1:45 PM | Cagliari Calcio | Virtus Entella | 6-5a.PSO/1-1FT |
| 8/16/25 2:15 PM | US Cremonese | Palermo FC | 4-5a.PSO/0-0FT |
| 8/17/25 11:00 AM | AC Monza | Frosinone Calcio | 0-1 |
| 8/17/25 11:30 AM | Parma Calcio 1913 | Pescara Calcio | 2-0 |
| 8/17/25 1:45 PM | FC Cesena | Pisa Sporting Club | 1-2a.PSO/0-0FT |
| 8/17/25 2:15 PM | AC Milan | SSC Bari | 2-0 |
| 8/18/25 11:00 AM | Audace Cerignola | Hellas Verona | 3-5a.PSO/1-1FT |
| 8/18/25 11:30 AM | Spezia Calcio | Sampdoria Genua | 5-3a.PSO/1-1FT |
| 8/18/25 1:45 PM | Udinese Calcio | Carrarese Calcio 1908 | 2-0 |
| 8/18/25 2:15 PM | FC Turin | Modena FC | 1-0 |
| 8/22/25 1:30 PM | Pescara Calcio | FC Cesena | 1-3 |
| 8/23/25 11:30 AM | Genua CFC | US Lecce | 0-0 |
| 8/23/25 11:30 AM | Sassuolo Calcio | SSC Napoli | 0-2 |
| 8/23/25 12:00 PM | Virtus Entella | Juve Stabia | 1-1 |
| 8/23/25 12:00 PM | FC Empoli | Padova Calcio | 3-1 |
| 8/23/25 1:45 PM | AC Milan | US Cremonese | 1-2 |
| 8/23/25 1:45 PM | AS Roma | FC Bologna | 1-0 |
| 8/23/25 2:00 PM | AC Monza | Mantova 1911 | 1-0 |
| 8/23/25 2:00 PM | Palermo FC | AC Reggiana 1919 | 2-1 |
| 8/24/25 11:30 AM | Como Calcio | Lazio Rom | 2-0 |
| 8/24/25 11:30 AM | Cagliari Calcio | Fiorentina | 1-1 |
| 8/24/25 12:00 PM | Spezia Calcio | Carrarese Calcio 1908 | 0-2 |
| 8/24/25 12:00 PM | FC Venice | SSC Bari | 2-1 |
| 8/24/25 1:45 PM | Atalanta Bergamo | Pisa Sporting Club | 1-1 |
| 8/24/25 1:45 PM | Juventus Turin | Parma Calcio 1913 | 2-0 |
| 8/24/25 2:00 PM | Frosinone Calcio | US Avellino | 2-0 |
| 8/24/25 2:00 PM | US Catanzaro 1929 | FC Südtirol | 1-1 |
| 8/25/25 11:30 AM | Udinese Calcio | Hellas Verona | 1-1 |
| 8/25/25 1:30 PM | Sampdoria Genua | Modena FC | 0-2 |
| 8/25/25 1:45 PM | Inter Milan | FC Turin | 5-0 |