Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/21/21 12:05 PM | 10/21/21 12:05 PM | HBW Balingen-Weilstetten | HSV Hamburg | 23-28 | 1 - 4 points |
| 10/21/21 12:05 PM | 10/21/21 12:05 PM | HC Erlangen | TSV Hannover-Burgdorf | 31-35 | 1 - 4 points |
| 10/21/21 12:05 PM | 10/21/21 12:05 PM | SC DHfK Leipzig | Frisch Auf Göppingen | 29-20 | 1 - 4 points |
| 10/21/21 12:05 PM | 10/21/21 12:05 PM | MT Melsungen | Bergischer HC | 26-24 | 1 - 4 points |
| 10/24/21 7:00 AM | 10/24/21 7:00 AM | THW Kiel | SC Magdeburg | 27-29 | 1 - 4 points |
| 10/24/21 9:00 AM | 10/24/21 9:00 AM | TSV GWD Minden | TBV Lemgo | 29-32 | 1 - 4 points |
| 10/24/21 9:00 AM | 10/24/21 9:00 AM | HSG Wetzlar | Rhein-Neckar-Löwen | 29-30 | 1 - 4 points |
| 10/24/21 9:00 AM | 10/24/21 9:00 AM | Füchse Berlin | TuS N-Lübbecke | 30-22 | 1 - 4 points |
| 10/24/21 9:00 AM | 10/24/21 9:00 AM | SG Flensburg-Handewitt | TVB 1898 Stuttgart | 30-29 | 1 - 4 points |