Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/30/21 12:05 PM | 9/30/21 12:05 PM | MT Melsungen | SC Magdeburg | 24-27 | 1 - 4 points |
| 10/9/21 11:30 AM | 10/9/21 11:30 AM | HBW Balingen-Weilstetten | TSV Hannover-Burgdorf | 28-26 | 1 - 4 points |
| 10/9/21 11:30 AM | 10/9/21 11:30 AM | HSG Wetzlar | Frisch Auf Göppingen | 28-28 | 1 - 4 points |
| 10/9/21 1:30 PM | 10/9/21 1:30 PM | TSV GWD Minden | TuS N-Lübbecke | 18-23 | 1 - 4 points |
| 10/9/21 1:30 PM | 10/9/21 1:30 PM | HC Erlangen | TBV Lemgo | 24-28 | 1 - 4 points |
| 10/10/21 7:00 AM | 10/10/21 7:00 AM | Füchse Berlin | THW Kiel | 28-28 | 1 - 4 points |
| 10/10/21 9:00 AM | 10/10/21 9:00 AM | Bergischer HC | Rhein-Neckar-Löwen | 25-25 | 1 - 4 points |
| 10/10/21 9:00 AM | 10/10/21 9:00 AM | SC DHfK Leipzig | TVB 1898 Stuttgart | 33-24 | 1 - 4 points |
| 10/10/21 9:00 AM | 10/10/21 9:00 AM | HSV Hamburg | SG Flensburg-Handewitt | 27-33 | 1 - 4 points |