Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/16/21 12:05 PM | 9/16/21 12:05 PM | TVB 1898 Stuttgart | Frisch Auf Göppingen | 27-34 | 1 - 4 points |
| 9/16/21 12:05 PM | 9/16/21 12:05 PM | TBV Lemgo | SC DHfK Leipzig | 26-27 | 1 - 4 points |
| 9/16/21 12:05 PM | 9/16/21 12:05 PM | MT Melsungen | Füchse Berlin | 25-33 | 1 - 4 points |
| 9/16/21 12:05 PM | 9/16/21 12:05 PM | SC Magdeburg | HSG Wetzlar | 30-26 | 1 - 4 points |
| 9/18/21 1:30 PM | 9/18/21 1:30 PM | HC Erlangen | TSV GWD Minden | 30-22 | 1 - 4 points |
| 9/19/21 6:40 AM | 9/19/21 6:40 AM | THW Kiel | SG Flensburg-Handewitt | 33-23 | 1 - 4 points |
| 9/19/21 9:00 AM | 9/19/21 9:00 AM | HSV Hamburg | Rhein-Neckar-Löwen | 32-27 | 1 - 4 points |
| 9/19/21 9:00 AM | 9/19/21 9:00 AM | TuS N-Lübbecke | HBW Balingen-Weilstetten | 33-27 | 1 - 4 points |
| 9/19/21 9:00 AM | 9/19/21 9:00 AM | TSV Hannover-Burgdorf | Bergischer HC | 28-20 | 1 - 4 points |