Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/11/21 11:30 AM | 9/11/21 11:30 AM | HBW Balingen-Weilstetten | TSV GWD Minden | 27-21 | 1 - 4 points |
| 9/11/21 11:30 AM | 9/11/21 11:30 AM | SG Flensburg-Handewitt | HC Erlangen | 27-27 | 1 - 4 points |
| 9/11/21 1:30 PM | 9/11/21 1:30 PM | MT Melsungen | THW Kiel | 26-33 | 1 - 4 points |
| 9/12/21 7:00 AM | 9/12/21 7:00 AM | Rhein-Neckar-Löwen | SC Magdeburg | 25-28 | 1 - 4 points |
| 9/12/21 9:00 AM | 9/12/21 9:00 AM | Bergischer HC | HSV Hamburg | 31-26 | 1 - 4 points |
| 9/12/21 9:00 AM | 9/12/21 9:00 AM | Frisch Auf Göppingen | TuS N-Lübbecke | 27-24 | 1 - 4 points |
| 9/12/21 9:00 AM | 9/12/21 9:00 AM | HSG Wetzlar | TBV Lemgo | 27-25 | 1 - 4 points |
| 9/12/21 9:00 AM | 9/12/21 9:00 AM | SC DHfK Leipzig | Füchse Berlin | 25-30 | 1 - 4 points |
| 12/12/21 9:00 AM | 12/12/21 9:00 AM | TVB 1898 Stuttgart | TSV Hannover-Burgdorf | 22-34 | 1 - 4 points |