Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/8/21 12:05 PM | 9/8/21 12:05 PM | HSV Hamburg | Frisch Auf Göppingen | 27-28 | 1 - 4 points |
| 9/8/21 12:05 PM | 9/8/21 12:05 PM | TSV GWD Minden | SG Flensburg-Handewitt | 18-31 | 1 - 4 points |
| 9/8/21 12:05 PM | 9/8/21 12:05 PM | HC Erlangen | SC DHfK Leipzig | 19-15 | 1 - 4 points |
| 9/8/21 12:05 PM | 9/8/21 12:05 PM | TBV Lemgo | MT Melsungen | 26-26 | 1 - 4 points |
| 9/8/21 12:15 PM | 9/8/21 12:15 PM | THW Kiel | HBW Balingen-Weilstetten | 33-24 | 1 - 4 points |
| 9/9/21 12:05 PM | 9/9/21 12:05 PM | Füchse Berlin | HSG Wetzlar | 29-24 | 1 - 4 points |
| 9/9/21 12:05 PM | 9/9/21 12:05 PM | TSV Hannover-Burgdorf | Rhein-Neckar-Löwen | 24-28 | 1 - 4 points |
| 9/9/21 12:05 PM | 9/9/21 12:05 PM | SC Magdeburg | TVB 1898 Stuttgart | 33-29 | 1 - 4 points |
| 9/9/21 12:05 PM | 9/9/21 12:05 PM | TuS N-Lübbecke | Bergischer HC | 20-24 | 1 - 4 points |