Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/11/21 8:30 AM | 9/11/21 8:25 AM | SpVgg Greuther Fürth | VfL Wolfsburg | 0-2 | 1 - 4 points |
| 9/11/21 8:30 AM | 9/11/21 8:25 AM | 1899 Hoffenheim | FSV Mainz 05 | 0-2 | 1 - 4 points |
| 9/11/21 8:30 AM | 9/11/21 8:25 AM | SC Freiburg | 1. FC Köln | 1-1 | 1 - 4 points |
| 9/11/21 8:30 AM | 9/11/21 8:25 AM | 1. FC Union Berlin | FC Augsburg | 0-0 | 1 - 4 points |
| 9/11/21 8:30 AM | 9/11/21 8:25 AM | Bayer 04 Leverkusen | Borussia Dortmund | 3-4 | 1 - 4 points |
| 9/11/21 11:30 AM | 9/11/21 11:25 AM | RB Leipzig | FC Bayern Munich | 1-4 | 1 - 4 points |
| 9/12/21 8:30 AM | 9/12/21 8:25 AM | Eintracht Frankfurt | VfB Stuttgart | 1-1 | 1 - 4 points |
| 9/12/21 10:30 AM | 9/12/21 10:25 AM | VfL Bochum | Hertha BSC | 1-3 | 1 - 4 points |
| 9/12/21 12:30 PM | 9/12/21 12:25 PM | Bor. Mönchengladbach | Arminia Bielefeld | 3-1 | 1 - 4 points |