Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/16/21 8:00 AM | 10/16/21 8:00 AM | Spezia Calcio | US Salernitana | 2-1 | 2 - 5 points |
| 10/16/21 11:00 AM | 10/16/21 11:00 AM | Lazio Rom | Inter Milan | 3-1 | 2 - 5 points |
| 10/16/21 1:50 PM | 10/16/21 1:50 PM | AC Milan | Hellas Verona | 3-2 | 2 - 5 points |
| 10/17/21 5:30 AM | 10/17/21 5:30 AM | Cagliari Calcio | Sampdoria Genua | 3-1 | 2 - 5 points |
| 10/17/21 8:00 AM | 10/17/21 8:00 AM | Udinese Calcio | FC Bologna | 1-1 | 2 - 5 points |
| 10/17/21 8:00 AM | 10/17/21 8:00 AM | Genua CFC | Sassuolo Calcio | 2-2 | 2 - 5 points |
| 10/17/21 8:00 AM | 10/17/21 8:00 AM | FC Empoli | Atalanta Bergamo | 1-4 | 2 - 5 points |
| 10/17/21 11:05 AM | 10/17/21 11:05 AM | SSC Napoli | FC Turin | 1-0 | 2 - 5 points |
| 10/17/21 1:45 PM | 10/17/21 1:45 PM | Juventus Turin | AS Roma | 1-0 | 2 - 5 points |
| 10/18/21 1:45 PM | 10/18/21 1:45 PM | FC Venice | Fiorentina | 1-0 | 2 - 5 points |