Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/25/21 8:00 AM | 9/25/21 8:00 AM | Spezia Calcio | AC Milan | 1-2 | 2 - 5 points |
| 9/25/21 11:00 AM | 9/25/21 11:00 AM | Inter Milan | Atalanta Bergamo | 2-2 | 2 - 5 points |
| 9/25/21 1:45 PM | 9/25/21 1:45 PM | Genua CFC | Hellas Verona | 3-3 | 2 - 5 points |
| 9/26/21 5:30 AM | 9/26/21 5:30 AM | Juventus Turin | Sampdoria Genua | 3-2 | 2 - 5 points |
| 9/26/21 8:00 AM | 9/26/21 8:00 AM | FC Empoli | FC Bologna | 4-2 | 2 - 5 points |
| 9/26/21 8:00 AM | 9/26/21 8:00 AM | Udinese Calcio | Fiorentina | 0-1 | 2 - 5 points |
| 9/26/21 8:00 AM | 9/26/21 8:00 AM | Sassuolo Calcio | US Salernitana | 1-0 | 2 - 5 points |
| 9/26/21 11:00 AM | 9/26/21 11:00 AM | Lazio Rom | AS Roma | 3-2 | 2 - 5 points |
| 9/26/21 1:45 PM | 9/26/21 1:45 PM | SSC Napoli | Cagliari Calcio | 2-0 | 2 - 5 points |
| 9/27/21 1:45 PM | 9/27/21 1:45 PM | FC Venice | FC Turin | 1-1 | 2 - 5 points |