Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/17/21 1:45 PM | 9/17/21 1:45 PM | Sassuolo Calcio | FC Turin | 0-1 | 2 - 5 points |
| 9/18/21 8:00 AM | 9/18/21 8:00 AM | Genua CFC | Fiorentina | 1-2 | 2 - 5 points |
| 9/18/21 11:00 AM | 9/18/21 11:00 AM | Inter Milan | FC Bologna | 6-1 | 2 - 5 points |
| 9/18/21 1:45 PM | 9/18/21 1:45 PM | US Salernitana | Atalanta Bergamo | 0-1 | 2 - 5 points |
| 9/19/21 5:30 AM | 9/19/21 5:30 AM | FC Empoli | Sampdoria Genua | 0-3 | 2 - 5 points |
| 9/19/21 8:00 AM | 9/19/21 8:00 AM | FC Venice | Spezia Calcio | 1-2 | 2 - 5 points |
| 9/19/21 11:00 AM | 9/19/21 11:00 AM | Hellas Verona | AS Roma | 3-2 | 2 - 5 points |
| 9/19/21 11:00 AM | 9/19/21 11:00 AM | Lazio Rom | Cagliari Calcio | 2-2 | 2 - 5 points |
| 9/19/21 1:45 PM | 9/19/21 1:45 PM | Juventus Turin | AC Milan | 1-1 | 2 - 5 points |
| 9/20/21 1:45 PM | 9/20/21 1:45 PM | Udinese Calcio | SSC Napoli | 0-4 | 2 - 5 points |