Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 10/19/21 11:45 AM | 10/19/21 11:45 AM | Club Brugge | Manchester City | Group A | 1-5 | 7 - 7 - 3 |
| 10/19/21 11:45 AM | 10/19/21 11:45 AM | Besiktas Istanbul | Sporting Lisbon | Group C | 1-4 | 5 - 5 - 4 |
| 10/19/21 2:00 PM | 10/19/21 2:00 PM | Schachtjor Donezk | Real Madrid | Group D | 0-5 | 7 - 7 - 3 |
| 10/19/21 2:00 PM | 10/19/21 2:00 PM | Inter Milan | Sheriff Tiraspol | Group D | 3-1 | 3 - 7 - 7 |
| 10/19/21 2:00 PM | 10/19/21 2:00 PM | FC Porto | AC Milan | Group B | 1-0 | 6 - 5 - 4 |
| 10/19/21 2:00 PM | 10/19/21 2:00 PM | Atletico Madrid | Liverpool FC | Group B | 2-3 | 7 - 5 - 3 |
| 10/19/21 2:00 PM | 10/19/21 2:00 PM | Paris St. Germain | RB Leipzig | Group A | 3-2 | 3 - 7 - 7 |
| 10/19/21 2:00 PM | 10/19/21 2:00 PM | Ajax Amsterdam | Borussia Dortmund | Group C | 4-0 | 7 - 6 - 3 |
| 10/20/21 11:45 AM | 10/20/21 11:45 AM | FC Red Bull Salzburg | VfL Wolfsburg | Group G | 3-1 | 4 - 5 - 5 |
| 10/20/21 11:45 AM | 10/20/21 11:45 AM | FC Barcelona | Dynamo Kiew | Group E | 1-0 | 3 - 7 - 7 |
| 10/20/21 2:00 PM | 10/20/21 2:00 PM | Chelsea FC | Malmö FF | Group H | 4-0 | 3 - 7 - 7 |
| 10/20/21 2:00 PM | 10/20/21 2:00 PM | Zenit St. Petersburg | Juventus Turin | Group H | 0-1 | 7 - 7 - 3 |
| 10/20/21 2:00 PM | 10/20/21 2:00 PM | OSC Lille | FC Sevilla | Group G | 0-0 | 7 - 5 - 4 |
| 10/20/21 2:00 PM | 10/20/21 2:00 PM | Benfica Lisbon | FC Bayern Munich | Group E | 0-4 | 7 - 7 - 3 |
| 10/20/21 2:00 PM | 10/20/21 2:00 PM | Young Boys Bern | FC Villarreal | Group F | 1-4 | 5 - 5 - 4 |
| 10/20/21 2:00 PM | 10/20/21 2:00 PM | Manchester United | Atalanta Bergamo | Group F | 3-2 | 3 - 7 - 7 |