| Date | Home | Away | Result |
|---|---|---|---|
| 3/12/22 8:30 AM | 1899 Hoffenheim | FC Bayern Munich | 1-1 |
| 3/12/22 8:30 AM | SC Freiburg | VfL Wolfsburg | 3-2 |
| 3/12/22 8:30 AM | 1. FC Union Berlin | VfB Stuttgart | 1-1 |
| 3/12/22 11:30 AM | Bor. Mönchengladbach | Hertha BSC | 2-0 |
| 3/13/22 9:30 AM | Bayer 04 Leverkusen | 1. FC Köln | 0-1 |
| 3/13/22 11:30 AM | Borussia Dortmund | Arminia Bielefeld | 1-0 |
| 3/13/22 11:30 AM | Eintracht Frankfurt | VfL Bochum | 2-1 |
| 3/13/22 1:30 PM | SpVgg Greuther Fürth | RB Leipzig | 1-6 |
| 4/6/22 11:30 AM | FC Augsburg | FSV Mainz 05 | 2-1 |