| Date | Home | Away | Result |
|---|---|---|---|
| 2/18/22 1:30 PM | FSV Mainz 05 | Bayer 04 Leverkusen | 3-2 |
| 2/19/22 8:30 AM | FC Augsburg | SC Freiburg | 1-2 |
| 2/19/22 8:30 AM | VfB Stuttgart | VfL Bochum | 1-1 |
| 2/19/22 8:30 AM | VfL Wolfsburg | 1899 Hoffenheim | 1-2 |
| 2/19/22 8:30 AM | Arminia Bielefeld | 1. FC Union Berlin | 1-0 |
| 2/19/22 11:30 AM | 1. FC Köln | Eintracht Frankfurt | 1-0 |
| 2/20/22 8:30 AM | FC Bayern Munich | SpVgg Greuther Fürth | 4-1 |
| 2/20/22 10:30 AM | Borussia Dortmund | Bor. Mönchengladbach | 6-0 |
| 2/20/22 12:30 PM | Hertha BSC | RB Leipzig | 1-6 |