| Date | Home | Away | Result |
|---|---|---|---|
| 2/11/22 1:30 PM | RB Leipzig | 1. FC Köln | 3-1 |
| 2/12/22 8:30 AM | Bor. Mönchengladbach | FC Augsburg | 3-2 |
| 2/12/22 8:30 AM | Eintracht Frankfurt | VfL Wolfsburg | 0-2 |
| 2/12/22 8:30 AM | SpVgg Greuther Fürth | Hertha BSC | 2-1 |
| 2/12/22 8:30 AM | VfL Bochum | FC Bayern Munich | 4-2 |
| 2/12/22 8:30 AM | SC Freiburg | FSV Mainz 05 | 1-1 |
| 2/12/22 11:30 AM | Bayer 04 Leverkusen | VfB Stuttgart | 4-2 |
| 2/13/22 8:30 AM | 1. FC Union Berlin | Borussia Dortmund | 0-3 |
| 2/13/22 10:30 AM | 1899 Hoffenheim | Arminia Bielefeld | 2-0 |