| Date | Home | Away | Result |
|---|---|---|---|
| 2/4/22 1:30 PM | Hertha BSC | VfL Bochum | 1-1 |
| 2/5/22 8:30 AM | VfB Stuttgart | Eintracht Frankfurt | 2-3 |
| 2/5/22 8:30 AM | 1. FC Köln | SC Freiburg | 1-0 |
| 2/5/22 8:30 AM | Arminia Bielefeld | Bor. Mönchengladbach | 1-1 |
| 2/5/22 8:30 AM | FC Augsburg | 1. FC Union Berlin | 2-0 |
| 2/5/22 8:30 AM | FSV Mainz 05 | 1899 Hoffenheim | 2-0 |
| 2/5/22 11:30 AM | FC Bayern Munich | RB Leipzig | 3-2 |
| 2/6/22 8:30 AM | Borussia Dortmund | Bayer 04 Leverkusen | 2-5 |
| 2/6/22 10:30 AM | VfL Wolfsburg | SpVgg Greuther Fürth | 4-1 |