| Date | Home | Away | Result |
|---|---|---|---|
| 1/21/22 1:30 PM | Eintracht Frankfurt | Arminia Bielefeld | 0-2 |
| 1/22/22 8:30 AM | Bor. Mönchengladbach | 1. FC Union Berlin | 1-2 |
| 1/22/22 8:30 AM | Bayer 04 Leverkusen | FC Augsburg | 5-1 |
| 1/22/22 8:30 AM | 1899 Hoffenheim | Borussia Dortmund | 2-3 |
| 1/22/22 8:30 AM | SC Freiburg | VfB Stuttgart | 2-0 |
| 1/22/22 8:30 AM | SpVgg Greuther Fürth | FSV Mainz 05 | 2-1 |
| 1/22/22 11:30 AM | VfL Bochum | 1. FC Köln | 2-2 |
| 1/23/22 8:30 AM | RB Leipzig | VfL Wolfsburg | 2-0 |
| 1/23/22 10:30 AM | Hertha BSC | FC Bayern Munich | 1-4 |