| Date | Home | Away | Result |
|---|---|---|---|
| 5/14/22 8:30 AM | VfB Stuttgart | 1. FC Köln | 2-1 |
| 5/14/22 8:30 AM | Bor. Mönchengladbach | 1899 Hoffenheim | 5-1 |
| 5/14/22 8:30 AM | 1. FC Union Berlin | VfL Bochum | 3-2 |
| 5/14/22 8:30 AM | Bayer 04 Leverkusen | SC Freiburg | 2-1 |
| 5/14/22 8:30 AM | Borussia Dortmund | Hertha BSC | 2-1 |
| 5/14/22 8:30 AM | Arminia Bielefeld | RB Leipzig | 1-1 |
| 5/14/22 8:30 AM | FC Augsburg | SpVgg Greuther Fürth | 2-1 |
| 5/14/22 8:30 AM | FSV Mainz 05 | Eintracht Frankfurt | 2-2 |
| 5/14/22 8:35 AM | VfL Wolfsburg | FC Bayern Munich | 2-2 |