| Date | Home | Away | Result |
|---|---|---|---|
| 4/22/22 1:30 PM | VfL Wolfsburg | FSV Mainz 05 | 5-0 |
| 4/23/22 8:30 AM | RB Leipzig | 1. FC Union Berlin | 1-2 |
| 4/23/22 8:30 AM | SpVgg Greuther Fürth | Bayer 04 Leverkusen | 1-4 |
| 4/23/22 8:30 AM | 1. FC Köln | Arminia Bielefeld | 3-1 |
| 4/23/22 8:30 AM | SC Freiburg | Bor. Mönchengladbach | 3-3 |
| 4/23/22 8:30 AM | Eintracht Frankfurt | 1899 Hoffenheim | 2-2 |
| 4/23/22 11:30 AM | FC Bayern Munich | Borussia Dortmund | 3-1 |
| 4/24/22 8:30 AM | VfL Bochum | FC Augsburg | 0-2 |
| 4/24/22 10:30 AM | Hertha BSC | VfB Stuttgart | 2-0 |