| Date | Home | Away | Result |
|---|---|---|---|
| 4/8/22 1:30 PM | VfB Stuttgart | Borussia Dortmund | 0-2 |
| 4/9/22 8:30 AM | 1. FC Köln | FSV Mainz 05 | 3-2 |
| 4/9/22 8:30 AM | VfL Wolfsburg | Arminia Bielefeld | 4-0 |
| 4/9/22 8:30 AM | FC Bayern Munich | FC Augsburg | 1-0 |
| 4/9/22 8:30 AM | SpVgg Greuther Fürth | Bor. Mönchengladbach | 0-2 |
| 4/9/22 11:30 AM | Hertha BSC | 1. FC Union Berlin | 1-4 |
| 4/10/22 8:30 AM | VfL Bochum | Bayer 04 Leverkusen | 0-0 |
| 4/10/22 10:30 AM | Eintracht Frankfurt | SC Freiburg | 1-2 |
| 4/10/22 12:30 PM | RB Leipzig | 1899 Hoffenheim | 3-0 |