| Date | Home | Away | Result |
|---|---|---|---|
| 1/7/22 1:30 PM | FC Bayern Munich | Bor. Mönchengladbach | 1-2 |
| 1/8/22 8:30 AM | SpVgg Greuther Fürth | VfB Stuttgart | 0-0 |
| 1/8/22 8:30 AM | 1899 Hoffenheim | FC Augsburg | 3-1 |
| 1/8/22 8:30 AM | SC Freiburg | Arminia Bielefeld | 2-2 |
| 1/8/22 8:30 AM | Bayer 04 Leverkusen | 1. FC Union Berlin | 2-2 |
| 1/8/22 8:30 AM | RB Leipzig | FSV Mainz 05 | 4-1 |
| 1/8/22 11:30 AM | Eintracht Frankfurt | Borussia Dortmund | 2-3 |
| 1/9/22 8:30 AM | Hertha BSC | 1. FC Köln | 1-3 |
| 1/9/22 10:30 AM | VfL Bochum | VfL Wolfsburg | 1-0 |