Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| DFB | 8/8/21 8:30 AM | 8/8/21 8:30 AM | FC Rot-Weiß Koblenz | Jahn Regensburg | 0-3 | 1 point |
| DFB | 8/8/21 8:30 AM | 8/8/21 8:30 AM | Türkgücü München | 1. FC Union Berlin | 0-1 | 1 point |
| DFB | 8/8/21 8:30 AM | 8/8/21 8:30 AM | SV Elversberg | FSV Mainz 05 | 9-10a.PSO | 1 point |
| DFB | 8/8/21 8:30 AM | 8/8/21 8:30 AM | FC Carl Zeiss Jena | 1. FC Köln | 3-5a.PSO | 1 point |
| DFB | 8/8/21 8:30 AM | 8/8/21 8:30 AM | SV Meppen | Hertha BSC | 0-1 | 1 point |
| DFB | 8/8/21 8:30 AM | 8/8/21 8:30 AM | VfL Oldenburg | Fortuna Düsseldorf | 0-5 | 1 point |
| DFB | 8/8/21 8:30 AM | 8/8/21 8:30 AM | FC 08 Villingen | FC Schalke 04 | 1-4 | 1 point |
| DFB | 8/8/21 11:30 AM | 8/8/21 11:30 AM | Eintracht Braunschweig | Hamburger SV | 1-2 | 1 point |
| DFB | 8/8/21 11:30 AM | 8/8/21 11:30 AM | FC Würzburger Kickers | SC Freiburg | 0-1 | 1 point |
| DFB | 8/8/21 11:30 AM | 8/8/21 11:30 AM | FC Hansa Rostock | 1. FC Heidenheim 1846 | 3-2a.e.t | 1 point |
| DFB | 8/9/21 11:30 AM | 8/9/21 11:30 AM | FC Viktoria Köln | 1899 Hoffenheim | 2-3a.e.t | 1 point |
| DFB | 8/9/21 11:30 AM | 8/9/21 11:30 AM | Sportfreunde Lotte | Karlsruher SC | 1-4 | 1 point |
| DFB | 8/9/21 11:30 AM | 8/9/21 11:30 AM | FC Ingolstadt | Erzgebirge Aue | 2-1 | 1 point |
| DFB | 8/9/21 1:45 PM | 8/9/21 1:45 PM | 1. FC Kaiserslautern | Bor. Mönchengladbach | 0-1 | 1 point |