| Date | Home | Away | Result |
|---|---|---|---|
| 10/22/21 1:30 PM | FSV Mainz 05 | FC Augsburg | 4-1 |
| 10/23/21 8:30 AM | RB Leipzig | SpVgg Greuther Fürth | 4-1 |
| 10/23/21 8:30 AM | FC Bayern Munich | 1899 Hoffenheim | 4-0 |
| 10/23/21 8:30 AM | Arminia Bielefeld | Borussia Dortmund | 1-3 |
| 10/23/21 8:30 AM | VfL Wolfsburg | SC Freiburg | 0-2 |
| 10/23/21 11:30 AM | Hertha BSC | Bor. Mönchengladbach | 1-0 |
| 10/24/21 8:30 AM | 1. FC Köln | Bayer 04 Leverkusen | 2-2 |
| 10/24/21 10:30 AM | VfB Stuttgart | 1. FC Union Berlin | 1-1 |
| 10/24/21 12:30 PM | VfL Bochum | Eintracht Frankfurt | 2-0 |