| Date | Home | Away | Result |
|---|---|---|---|
| 9/30/22 1:30 PM | FC Bayern Munich | Bayer 04 Leverkusen | 4-0 |
| 10/1/22 8:30 AM | RB Leipzig | VfL Bochum | 4-0 |
| 10/1/22 8:30 AM | SC Freiburg | FSV Mainz 05 | 2-1 |
| 10/1/22 8:30 AM | 1. FC Köln | Borussia Dortmund | 3-2 |
| 10/1/22 8:30 AM | VfL Wolfsburg | VfB Stuttgart | 3-2 |
| 10/1/22 8:30 AM | Eintracht Frankfurt | 1. FC Union Berlin | 2-0 |
| 10/1/22 11:30 AM | Werder Bremen | Bor. Mönchengladbach | 5-1 |
| 10/2/22 8:35 AM | Hertha BSC | 1899 Hoffenheim | 1-1 |
| 10/2/22 10:30 AM | FC Schalke 04 | FC Augsburg | 2-3 |