| Date | Home | Away | Result |
|---|---|---|---|
| 10/15/21 1:30 PM | 1899 Hoffenheim | 1. FC Köln | 5-0 |
| 10/16/21 8:30 AM | 1. FC Union Berlin | VfL Wolfsburg | 2-0 |
| 10/16/21 8:30 AM | Eintracht Frankfurt | Hertha BSC | 1-2 |
| 10/16/21 8:30 AM | Borussia Dortmund | FSV Mainz 05 | 3-1 |
| 10/16/21 8:30 AM | SpVgg Greuther Fürth | VfL Bochum | 0-1 |
| 10/16/21 8:30 AM | SC Freiburg | RB Leipzig | 1-1 |
| 10/16/21 11:30 AM | Bor. Mönchengladbach | VfB Stuttgart | 1-1 |
| 10/17/21 8:30 AM | Bayer 04 Leverkusen | FC Bayern Munich | 1-5 |
| 10/17/21 10:30 AM | FC Augsburg | Arminia Bielefeld | 1-1 |