| Date | Home | Away | Result |
|---|---|---|---|
| 9/16/22 1:30 PM | FSV Mainz 05 | Hertha BSC | 1-1 |
| 9/17/22 8:30 AM | VfB Stuttgart | Eintracht Frankfurt | 1-3 |
| 9/17/22 8:30 AM | FC Augsburg | FC Bayern Munich | 1-0 |
| 9/17/22 8:30 AM | Bayer 04 Leverkusen | Werder Bremen | 1-1 |
| 9/17/22 8:30 AM | Borussia Dortmund | FC Schalke 04 | 1-0 |
| 9/17/22 11:30 AM | Bor. Mönchengladbach | RB Leipzig | 3-0 |
| 9/18/22 8:30 AM | 1. FC Union Berlin | VfL Wolfsburg | 2-0 |
| 9/18/22 10:30 AM | VfL Bochum | 1. FC Köln | 1-1 |
| 9/18/22 12:30 PM | 1899 Hoffenheim | SC Freiburg | 0-0 |