| Date | Home | Away | Result |
|---|---|---|---|
| 10/1/21 1:30 PM | 1. FC Köln | SpVgg Greuther Fürth | 3-1 |
| 10/2/21 8:30 AM | Hertha BSC | SC Freiburg | 1-2 |
| 10/2/21 8:30 AM | VfB Stuttgart | 1899 Hoffenheim | 3-1 |
| 10/2/21 8:30 AM | VfL Wolfsburg | Bor. Mönchengladbach | 1-3 |
| 10/2/21 8:30 AM | Borussia Dortmund | FC Augsburg | 2-1 |
| 10/2/21 11:30 AM | RB Leipzig | VfL Bochum | 3-0 |
| 10/3/21 8:30 AM | FSV Mainz 05 | 1. FC Union Berlin | 1-2 |
| 10/3/21 10:30 AM | FC Bayern Munich | Eintracht Frankfurt | 1-2 |
| 10/3/21 12:30 PM | Arminia Bielefeld | Bayer 04 Leverkusen | 0-4 |