| Date | Home | Away | Result |
|---|---|---|---|
| 9/24/21 1:30 PM | SpVgg Greuther Fürth | FC Bayern Munich | 1-3 |
| 9/25/21 8:30 AM | Eintracht Frankfurt | 1. FC Köln | 1-1 |
| 9/25/21 8:30 AM | RB Leipzig | Hertha BSC | 6-0 |
| 9/25/21 8:30 AM | 1899 Hoffenheim | VfL Wolfsburg | 3-1 |
| 9/25/21 8:30 AM | 1. FC Union Berlin | Arminia Bielefeld | 1-0 |
| 9/25/21 8:30 AM | Bayer 04 Leverkusen | FSV Mainz 05 | 1-0 |
| 9/25/21 11:30 AM | Bor. Mönchengladbach | Borussia Dortmund | 1-0 |
| 9/26/21 8:30 AM | VfL Bochum | VfB Stuttgart | 0-0 |
| 9/26/21 10:30 AM | SC Freiburg | FC Augsburg | 3-0 |