| Date | Home | Away | Result |
|---|---|---|---|
| 9/2/22 1:30 PM | Borussia Dortmund | 1899 Hoffenheim | 1-0 |
| 9/3/22 8:30 AM | VfL Wolfsburg | 1. FC Köln | 2-4 |
| 9/3/22 8:30 AM | 1. FC Union Berlin | FC Bayern Munich | 1-1 |
| 9/3/22 8:30 AM | VfB Stuttgart | FC Schalke 04 | 1-1 |
| 9/3/22 8:30 AM | Bayer 04 Leverkusen | SC Freiburg | 2-3 |
| 9/3/22 8:30 AM | VfL Bochum | Werder Bremen | 0-2 |
| 9/3/22 11:30 AM | Eintracht Frankfurt | RB Leipzig | 4-0 |
| 9/4/22 8:30 AM | FC Augsburg | Hertha BSC | 0-2 |
| 9/4/22 10:30 AM | Bor. Mönchengladbach | FSV Mainz 05 | 0-1 |