| Date | Home | Away | Result |
|---|---|---|---|
| 9/17/21 1:30 PM | Hertha BSC | SpVgg Greuther Fürth | 2-1 |
| 9/18/21 8:30 AM | FC Bayern Munich | VfL Bochum | 7-0 |
| 9/18/21 8:30 AM | Arminia Bielefeld | 1899 Hoffenheim | 0-0 |
| 9/18/21 8:30 AM | FC Augsburg | Bor. Mönchengladbach | 1-0 |
| 9/18/21 8:30 AM | FSV Mainz 05 | SC Freiburg | 0-0 |
| 9/18/21 11:30 AM | 1. FC Köln | RB Leipzig | 1-1 |
| 9/19/21 8:30 AM | VfB Stuttgart | Bayer 04 Leverkusen | 1-3 |
| 9/19/21 10:30 AM | Borussia Dortmund | 1. FC Union Berlin | 4-2 |
| 9/19/21 12:30 PM | VfL Wolfsburg | Eintracht Frankfurt | 1-1 |