| Date | Home | Away | Result |
|---|---|---|---|
| 9/11/21 8:30 AM | SpVgg Greuther Fürth | VfL Wolfsburg | 0-2 |
| 9/11/21 8:30 AM | 1899 Hoffenheim | FSV Mainz 05 | 0-2 |
| 9/11/21 8:30 AM | SC Freiburg | 1. FC Köln | 1-1 |
| 9/11/21 8:30 AM | 1. FC Union Berlin | FC Augsburg | 0-0 |
| 9/11/21 8:30 AM | Bayer 04 Leverkusen | Borussia Dortmund | 3-4 |
| 9/11/21 11:30 AM | RB Leipzig | FC Bayern Munich | 1-4 |
| 9/12/21 8:30 AM | Eintracht Frankfurt | VfB Stuttgart | 1-1 |
| 9/12/21 10:30 AM | VfL Bochum | Hertha BSC | 1-3 |
| 9/12/21 12:30 PM | Bor. Mönchengladbach | Arminia Bielefeld | 3-1 |