| Date | Home | Away | Result |
|---|---|---|---|
| 4/29/22 1:30 PM | 1. FC Union Berlin | SpVgg Greuther Fürth | 1-1 |
| 4/30/22 8:30 AM | Arminia Bielefeld | Hertha BSC | 1-1 |
| 4/30/22 8:30 AM | FC Augsburg | 1. FC Köln | 1-4 |
| 4/30/22 8:30 AM | FSV Mainz 05 | FC Bayern Munich | 3-1 |
| 4/30/22 8:30 AM | VfB Stuttgart | VfL Wolfsburg | 1-1 |
| 4/30/22 8:30 AM | Borussia Dortmund | VfL Bochum | 3-4 |
| 4/30/22 11:30 AM | 1899 Hoffenheim | SC Freiburg | 3-4 |
| 5/2/22 1:30 PM | Bor. Mönchengladbach | RB Leipzig | 3-1 |
| 5/2/22 1:30 PM | Bayer 04 Leverkusen | Eintracht Frankfurt | 2-0 |