| Date | Home | Away | Result |
|---|---|---|---|
| 8/27/21 1:30 PM | Borussia Dortmund | 1899 Hoffenheim | 3-2 |
| 8/28/21 8:30 AM | FC Augsburg | Bayer 04 Leverkusen | 1-4 |
| 8/28/21 8:30 AM | FSV Mainz 05 | SpVgg Greuther Fürth | 3-0 |
| 8/28/21 8:30 AM | VfB Stuttgart | SC Freiburg | 2-3 |
| 8/28/21 8:30 AM | 1. FC Köln | VfL Bochum | 2-1 |
| 8/28/21 8:30 AM | Arminia Bielefeld | Eintracht Frankfurt | 1-1 |
| 8/28/21 11:30 AM | FC Bayern Munich | Hertha BSC | 5-0 |
| 8/29/21 8:30 AM | 1. FC Union Berlin | Bor. Mönchengladbach | 2-1 |
| 8/29/21 10:30 AM | VfL Wolfsburg | RB Leipzig | 1-0 |