| Date | Home | Away | Result |
|---|---|---|---|
| 4/1/22 1:30 PM | 1. FC Union Berlin | 1. FC Köln | 1-0 |
| 4/2/22 8:30 AM | Eintracht Frankfurt | SpVgg Greuther Fürth | 0-0 |
| 4/2/22 8:30 AM | Arminia Bielefeld | VfB Stuttgart | 1-1 |
| 4/2/22 8:30 AM | 1899 Hoffenheim | VfL Bochum | 1-2 |
| 4/2/22 8:30 AM | SC Freiburg | FC Bayern Munich | 1-4 |
| 4/2/22 8:30 AM | Bayer 04 Leverkusen | Hertha BSC | 2-1 |
| 4/2/22 11:30 AM | Borussia Dortmund | RB Leipzig | 1-4 |
| 4/3/22 8:30 AM | FC Augsburg | VfL Wolfsburg | 3-0 |
| 4/3/22 10:30 AM | Bor. Mönchengladbach | FSV Mainz 05 | 1-1 |