| Date | Home | Away | Result |
|---|---|---|---|
| 3/18/22 2:30 PM | VfL Bochum | Bor. Mönchengladbach | 0-2 |
| 3/19/22 9:30 AM | SpVgg Greuther Fürth | SC Freiburg | 0-0 |
| 3/19/22 9:30 AM | Hertha BSC | 1899 Hoffenheim | 3-0 |
| 3/19/22 9:30 AM | FSV Mainz 05 | Arminia Bielefeld | 4-0 |
| 3/19/22 9:30 AM | VfB Stuttgart | FC Augsburg | 3-2 |
| 3/19/22 12:30 PM | FC Bayern Munich | 1. FC Union Berlin | 4-0 |
| 3/20/22 9:30 AM | RB Leipzig | Eintracht Frankfurt | 0-0 |
| 3/20/22 11:30 AM | VfL Wolfsburg | Bayer 04 Leverkusen | 0-2 |
| 3/20/22 1:30 PM | 1. FC Köln | Borussia Dortmund | 1-1 |