| Date | Home | Away | Result |
|---|---|---|---|
| 3/4/22 1:30 PM | Arminia Bielefeld | FC Augsburg | 0-1 |
| 3/5/22 8:30 AM | Hertha BSC | Eintracht Frankfurt | 1-4 |
| 3/5/22 8:30 AM | FC Bayern Munich | Bayer 04 Leverkusen | 1-1 |
| 3/5/22 8:30 AM | VfL Wolfsburg | 1. FC Union Berlin | 1-0 |
| 3/5/22 8:30 AM | RB Leipzig | SC Freiburg | 1-1 |
| 3/5/22 8:30 AM | VfL Bochum | SpVgg Greuther Fürth | 2-1 |
| 3/5/22 11:30 AM | VfB Stuttgart | Bor. Mönchengladbach | 3-2 |
| 3/6/22 10:30 AM | 1. FC Köln | 1899 Hoffenheim | 0-1 |
| 3/16/22 12:30 PM | FSV Mainz 05 | Borussia Dortmund | 0-1 |