| Date | Home | Away | Result |
|---|---|---|---|
| 2/25/22 1:30 PM | 1899 Hoffenheim | VfB Stuttgart | 2-1 |
| 2/26/22 8:30 AM | SC Freiburg | Hertha BSC | 3-0 |
| 2/26/22 8:30 AM | Bor. Mönchengladbach | VfL Wolfsburg | 2-2 |
| 2/26/22 8:30 AM | 1. FC Union Berlin | FSV Mainz 05 | 3-1 |
| 2/26/22 8:30 AM | Bayer 04 Leverkusen | Arminia Bielefeld | 3-0 |
| 2/26/22 8:30 AM | SpVgg Greuther Fürth | 1. FC Köln | 1-1 |
| 2/26/22 11:30 AM | Eintracht Frankfurt | FC Bayern Munich | 0-1 |
| 2/27/22 8:30 AM | VfL Bochum | RB Leipzig | 0-1 |
| 2/27/22 10:30 AM | FC Augsburg | Borussia Dortmund | 1-1 |