| Date | Home | Away | Result |
|---|---|---|---|
| 8/20/21 1:30 PM | RB Leipzig | VfB Stuttgart | 4-0 |
| 8/21/21 8:30 AM | SpVgg Greuther Fürth | Arminia Bielefeld | 1-1 |
| 8/21/21 8:30 AM | VfL Bochum | FSV Mainz 05 | 2-0 |
| 8/21/21 8:30 AM | SC Freiburg | Borussia Dortmund | 2-1 |
| 8/21/21 8:30 AM | Eintracht Frankfurt | FC Augsburg | 0-0 |
| 8/21/21 8:35 AM | Hertha BSC | VfL Wolfsburg | 1-2 |
| 8/21/21 11:30 AM | Bayer 04 Leverkusen | Bor. Mönchengladbach | 4-0 |
| 8/22/21 8:30 AM | 1899 Hoffenheim | 1. FC Union Berlin | 2-2 |
| 8/22/21 10:30 AM | FC Bayern Munich | 1. FC Köln | 3-2 |