| Date | Home | Away | Result |
|---|---|---|---|
| 1/14/22 1:30 PM | Borussia Dortmund | SC Freiburg | 5-1 |
| 1/15/22 8:30 AM | FSV Mainz 05 | VfL Bochum | 1-0 |
| 1/15/22 8:30 AM | VfB Stuttgart | RB Leipzig | 0-2 |
| 1/15/22 8:30 AM | 1. FC Union Berlin | 1899 Hoffenheim | 2-1 |
| 1/15/22 8:30 AM | VfL Wolfsburg | Hertha BSC | 0-0 |
| 1/15/22 8:30 AM | 1. FC Köln | FC Bayern Munich | 0-4 |
| 1/15/22 11:30 AM | Bor. Mönchengladbach | Bayer 04 Leverkusen | 1-2 |
| 1/16/22 8:30 AM | FC Augsburg | Eintracht Frankfurt | 1-1 |
| 1/16/22 10:30 AM | Arminia Bielefeld | SpVgg Greuther Fürth | 2-2 |